New Drugs Approval

Image   1) Zeposia (ozanimod) Capsules  Company: Bristol-Myers Squibb Company  Date of Approval: March 25, 2020  Treatment for: Multiple Sclerosis  Zeposia (ozanimod) is a sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis (MS).  2) Isturisa (osilodrostat) Tablets  Company: Novartis Pharmaceuticals Corporation  Date of Approval: March 6, 2020  Treatment for: Cushing's Syndrome    Isturisa (osilodrostat) is a cortisol synthesis inhibitor indicated for the treatment of adult patients with Cushing’s disease.  3) Durysta (bimatoprost) Implant  ... Read More

The Importance of Medicines

Image There has been a spate of drug related illnesses and deaths reported from Pakistan in the press this year. In November, at least 17 people died in the eastern city of Lahore after drinking toxic cough syrup. Earlier in January, an adulterated heart medicine dispensed by the Punjab Institute of Cardiology claimed lives of at least 69 heart patients. It seems appropriate to put these happenings in some perspective.   Cough syrups have been at the center of several cases of mass poisonings around the world in recent years, often involving accidental or intentional use of... Read More

How Are Diseases Transmitted?

Image Overview  Infectious diseases are transmitted from person to person by direct or indirect contact. Certain types of viruses, bacteria, parasites, and fungi can all cause infectious disease. Malaria, measles, and respiratory illnesses are examples of infectious diseases.  Simple preventative measures, such as frequent hand washing, can cut down on disease transmission.   Direct contact  Infectious diseases are often spread through direct contact. Types of direct contact include:   1. Person-to-person contact  Infectious diseases are commonly transmitted through direct person-to-person contact. Transmission occurs when an infected person... Read More

Cell receptors are generally transmembrane proteins

Image Author Name: Keith Howell Category Name: Medical science Description:  Cells have proteins called receptors that bind to signaling molecules and initiate a physiological response. Different receptors are specific for different molecules. Dopamine receptors bind dopamine, insulin receptors bind insulin, nerve growth factor receptors bind nerve growth factor, and so on. In fact, there are hundreds of receptor types found in cells, and varying cell types have different populations of receptors. Receptors can also respond directly to light or pressure, which makes cells sensitive to events in the atmosphere. Receptors are generally transmembrane proteins, which bind to signaling molecules... Read More

New approaches for treatment of Infectious Diseases

Image The problem of antibiotic resistance in bacteria has reached the crisis stage. Coincident with ever-increasing rates of resistance to conventional antibiotics is the slowing in development of novel-acting antibiotics by the pharmaceutical industry. The convergence of these trends has led to the relatively common occurrence of multidrug- and extensively drug-resistant bacteria. The World Health Organization recently reported that “a postantibiotic era—in which common infections and minor injuries can kill—far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century”. To fathom such a future, one need only ponder the past. At the beginning... Read More

Chromatography is the most widely used separation technique in chemical laboratories

Image Chromatography is the most widely used separation technique in chemical laboratories, where it is used in analysis, isolation and purification, and it is commonly used in the chemical process industry as a component of small and large-scale production. In terms of scale, at one extreme minute quantities of less than a nanogram are separated and identified during analysis, while at the other, hundreds of kilograms of material per hour are processed into refined products. It is the versatility of chromatography in its many variants that is behind its ubiquitous status in separation science, coupled with simplicity of approach and a... Read More

Drug Absorption

Image Absorption is the transfer of the drug into the bloodstream. In IV this process is complete thus the whole dose reaches the systemic circulation. However in other routes of administration the rate and efficiency is dependent on many factors and usually on ly results in partial absorption. Transport in GIT Due to their chemical properties, drugs are absorbed either by passive diffusion or active transport. Passive diffusion: Passive diffusion is facilitated by the concentration gradient accross the membrane. The drug moves from high concentration to low concentration, it does not require an extra carrier or extra energy. Water-soluble agents use... Read More

Probiotics in clinical practice

Image The interaction of the gastrointestinal microflora with the human host has been the subject of considerable debate in the last decade. Manipulation of the enteric microflora with probiotic organisms has been attempted in a wide range of clinical settings, in the hope of achieving health benefits in the host. This review presents the evidence from human clinical trials of probiotics in the areas of diarrhoeal illness, inflammatory bowel disease, surgical prophylaxis, critical care and serum lipid modulation. With the exception of childhood viral diarrhoea, there is little evidence... Read More

Probiotic activities of Lactobacillus casei rhamnosus

Image The interest of probiotics as remedies for a broad number of gastrointestinal and other infectious diseases has gained wide interest over the last few years, but little is known about their underlying mechanism of action. The inhibitory effects of Lcr35 organisms on the adherence of three pathogens, enteropathogenic Escherichia coli (EPEC), enterotoxigenic E. coli (ETEC) and Klebsiella pneumoniae, were determined. A decrease in the number of adhering pathogens was observed, using either preincubation, postincubation or coincubation of the pathogens with Lcr35. Moreover, the antibacterial activities of cell-free Lcr35 supernatant was examined against nine human... Read More

Drug Analysis

Image What is Drugs Analysis? Within forensic science the role of the drugs section is to prove to a satisfactory level to the court, including the defence, what a substance is and ascertain whether or not it contains any drugs controlled under current legislation. To do this to the level required by the court involves performing a chemical analysis.  As well as determining exactly what drug may be in a given substance (qualitative analysis), further chemical analysis can determine the amount of the drug present and thereby provide the purity of the substance (quantitative analysis). How We Analyse Drugs There are... Read More

Mineral Nutrient Sensing and Signaling

Image Macronutrients such as nitrogen, phosphate, sulphate and micronutrients such as iron, copper and zinc are essential for various aspects of plant growth and development, but these elements may also be toxic if accumulated in the plant cell in excess. Non-essential elements like cadmium, arsenic, and aluminum are potentially highly toxic; however they are increasingly being emitted into the environment due to anthropogenic activities. Soils often challenge sessile plants with poor availability of essential minerals or elevated concentrations of toxic elements. These challenges are often exacerbated by soil type. For example, NO3− is the main source of inorganic nitrogen for plants... Read More

Hormone Receptors and Breast Cancer

Image Breast cancer is the most commonly diagnosed cancer in women worldwide and is the second leading cause of cancer-related deaths. The vast majority of breast cancers arise from epithelial cells, either in the ducts or lobules, as a consequence of genetic and epigenetic alterations, which lead to aberrant growth control and disruption of intracellular signalling at the tissue level. For these reasons, breast cancer is a heterogeneous disease with multiple sub-types, with distinct cells of origin and etiology. The increased expression of estrogen receptors (ER), that occurs at the earlier stages of breast tumor development and is common to different... Read More

Biosensor H2O2 by Using Immobilized Horseradish Peroxidase Glutaraldehyde

Image An enzymatic biosensor has been developed for detection of hydrogen peroxide with immobilized Horseradish peroxidase (HRP). HRP was immobilized by using glutaraldehyde (GA) that cross linked with modified polyaniline (PANI) as mediator to improve electron transfer. Modified carbon paste electrodes (MCPE) PANI was more effective during electron transfer compared to carbon paste electrodes (CPE). Cyclic voltammetry method (VC) was used to determine the electrochemical properties of the modified electrode substrate to produce redox reactions. The effect of pH and temperature were analysed by cyclic voltammetry. The optimum performance of HRP/GA/PANI was at pH 7 and 50°C. Kinetics parameters HRP enzyme... Read More

Enzyme Enabled Antibiotic Production

Image Manufacturing is the life line and driver of economic development; by producing goods we not only achieve growth but also vastly improve our quality of life. Manufacturing in simple terms means taking certain raw materials and converting them into value added products and invariably nuisance value by-products or creating eco-impact at various levels and with more. In addition, consumption of the key material from the nature depletes the same and without a concerted eco-responsible effort the natural resource is lost for ever. Green Manufacturing Enabling Sustainability A paradigm shift in manufacturing mind-set, defined figuratively as “Green manufacturing” has emerged as... Read More

N-Acetyl Cysteine Decreases Mice Brain Acetyl Cholinesterase Activity

Image Here a kinetic in vitro study of n-acetylcysteine (NAC) on mouse brain acetylcholinesterase (AChE) activity was performed, as well, few studies with the aim to improve Ellman’s methodology based on SH contain compounds. The ideal 5,5´-dithio-bis-2-nitrobenzoic acid (DTNB) concentration was of 0.3 mM and ideal medium pH=7.4. AChE demonstrated linear activity for all acetylthiocholine iodide (ATCh) tested concentrations (0.025-0.450 mM). To avoid any DTNB-NAC interaction interference, 30 sec were applied to the assay method, so-called stabilization time. No differences in Km (mM) for all NAC tested concentrations were observed. At the NAC concentrations started from 75 µM significant differences in... Read More

Lipase Catalysed Trans Esterification

Image   There has been great emphasis on the use of biodiesel due to worldwide scarcity of fossil fuels, increasing crude oil prices and environmental concerns to reduce pollution. Production of biodiesel from biologically derived oils involves trans esterification of these triglycerides with short chain alcohols to yield alkyl esters of fatty acids. These can be used in engines which are having compression ignition (diesel) and are termed as “biodiesel”. Trans esterification catalysis reaction can be chemical and enzymatic by nature. The disadvantages of chemical synthesis processes (for instance expenditure of high energy, triglycerides trans esterification with high free fatty acid... Read More

Perioperative Management Access of Peritonitis at the Regional University Hospital of Oueme-Plateau (CHUD/OP) at Porto-Novo in Benin Republic

Image Journal of Perioperative Medicine is a peer reviewed, open access periodical that underlines the importance of pre-operative medical care, procedures and protocols in assuring stress free and healthy post-operative life of the patient. Journal of Perioperative Medicine is spotlight on Local Anesthesia, Sedation, Regional Anesthesia, Anesthetic Agents, Nerve Blocks, Spinal, Epidural and Caudal Anesthesia, General Anesthesia, Thoracic Anesthesiology, Pediatric Anesthesiology, Obstetric Anesthesiology, Analgesics, Anesthesia & Critical Care, Spinal Anesthesia, Anesthetics, Epidural Anesthesia, Clinical Anesthesia, Dental Anesthesia, Vascular Anesthesia, and Surgical Anesthesia. Journal of Perioperative Medicine thus caters to a wide range... Read More

The Genetics and Genomics of Melanoma and Benign Melanocytic Neoplasms

Image This collated research topic comprises three main sections: 1) Genetic susceptibility of melanoma and benign melanocytic neoplasms; 2) genomic analysis/molecular characterization of melanoma and benign melanocytic neoplasms; and 3) biomarkers of melanoma progression. Melanoma is a malignant neoplasm that arises from melanocytes of the skin and other organs. The incidence of cutaneous melanoma, which is the most aggressive of the common skin cancers, is rapidly increasing especially in Caucasian populations. Melanocyte transformation occurs when DNA repair or cell-cycle control mechanisms are damaged, which in cutaneous melanoma, is largely due to repeated insult by ultra-violet radiation (UVR). In most cases melanocyte... Read More

Strategies in the treatment of Melanoma

Image For many years melanoma was considered a significant challenge by oncologists. In 2011 the story changed because of the approval of ipilimumab, an anti-CTLA4 monoclonal antibody, and vemurafenib, a BRAF inhibitor active on BRAF mutated melanoma. These two revolutionary drugs completely changed the management of metastatic melanoma and, for the first time, became possible to achieve a significative impact on overall survival. To improve the efficacy of ipilimumab and vemurafenib have been designed clinical trials, now ongoing, of combination with other targeted agents (e.g. MEK inhibitors) and immunotherapeutic compounds (e.g. anti-PD-L1). Other possible combinations of these two new drugs can... Read More

Prioritisation of quality indicators for elective perioperative care: a Delphi consensus

Image Journal of Perioperative Medicine publishes high-impact original work in all branches of anaesthesia, critical care medicine, pain medicine and perioperative medicine including fundamental, translational and clinical sciences, clinical practice, technology, education and training. The journal has a well-respected editorial board and provides a sharp focus on the topics and issues facing the profession of Internal Medicine with a combination of society news, clinical and scientific original articles. Journal of Perioperative Medicine is successfully running in the Volume 2 which covers a wide variety of specialties reaching out to analytical scientists worldwide. Journal of Perioperative... Read More

Relationships between Anti-mullerian Hormone, Testosterone, Luteinizing Hormone and Follicle Stimulating Hormone in Men on Testosterone Therapy

Image Clinical & Medical Biochemistry journal is a scholarly Open Access journal maintains high standards of scientific excellence and its editorial board promises a rapid peer review process with the help of the Editorial Manager System. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical... Read More

Regeneration of Cutaneous Wounds and Inflammation in Healing

Image   Cutaneous wounds are a largely unrecognized, spiraling epidemic that affects millions of people worldwide. Healing and regeneration of wounds is a complex process that has at its core a functional inflammatory response that initiates the repair process and fights against infective pathogens. Wound inflammation is a tightly regulated process involving neutrophils, macrophages, mast cells, and various leukocytes and tissue restoration mechanisms working in concert to allow healing and tissue restoration following injury. However, in many conditions, dysregulated and/or prolonged inflammation leads to the development of chronic wounds and contributes to excessive scar formation. Over the past few decades, scientific... Read More

Wound recognition across the tree of life

Image All multicellular organisms must detect injury to mount adequate responses. Plants respond with induced resistance, animals with local immunity and regeneration, and fungi exhibit wound-induced conidiation. Intact cells perceive damage-associated molecular patters (DAMPs) in the extracellular space as 'danger signals' to recognise damage before infection occurs. Molecules such as extracellular ATP and fragments of the cell wall or the extra- or intracellular matrix function as DAMPs in organisms across different kingdoms. All these DAMPs represent fragments of larger molecules or intracellular molecules. Thus, their occurrence in the extracellular space indicates the presence of damaged cells. This model, originally promoted by... Read More

Non Pharmacological Use of Daucus Carota Juice (Carrot Juice) as Dietary Intervention in Reducing Hypertension

Image The word diuresis is derived from the Greek word ourein which means ‘’to urinate’’. The diuretic agents are not only involved in the excretion of water but also capable to remove or excrete other urinary constituents which may be beneficial in the treatment of different conditions like hypertension, edema. Diuretic agents reduce morbidity and mortality related to stroke and congestive heart failure in hypertensive patients. Hypertension can be defined as sustained increase in systolic blood pressure greater than 140 mmHg and diastolic pressure greater than 90 mmHg. Generally hypertension is classified into two types, based on the causes i.e., Primary... Read More

Emerging the Field Of Enzyme Engineering

Image On behalf of our esteemed journal Enzyme Engineering (Longdom Publishers SL) is a scientific open access journal that specifies and describes the development activities conducted in the field of Medical Science. The objective of the journal is to provide a medium for scientific communication to confer about the recent advancements in Enzymology. The Editorial Board of our Enzyme Engineering Journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some... Read More

Impacted Cera Septal Occluder Device in Right Ventricular Outflow Tract (RVOT): A Potential Challenge for the Anesthesiologist

Image Journal of Perioperative Medicine publishes original work of high scientific quality. Preference is given to experimental work or clinical observation in man, and to laboratory work of clinical relevance. Journal of Perioperative Medicine also publishes commissioned narrative reviews by an authority in a field of interest to those working in anaesthesiology, pain, emergency medicine or intensive care. Editorials, commissioned commentaries and book reviews also included. Journal of Perioperative Medicine a wide range of articles in the discipline of anesthesiology including basic science, translational medicine, education, and clinical research to create a platform for the... Read More

Emergent needle decompression for tension pneumothorax resulting in life threatening intercostal artery injury

Image Journal of Perioperative Medicine aims to promote publications from anesthesia care providers who are otherwise unable to access other journals. Most importantly, those anesthesia care providers from countries or regions that have few resources to provide anesthesia care or approaches to perioperative medicine now have a forum to publish their approaches, research, and dilemmas in patient management. Journal of Perioperative Medicine provides a broader platform to discuss a wide range of topics in this field including Local Anesthesia, Sedation, Regional Anesthesia, Anesthetic Agents, Nerve Blocks, Spinal, Epidural and Caudal Anesthesia, General Anesthesia, Thoracic Anesthesiology,... Read More

A Pediatric Perspective on Stem Cells: Expression, Function and Clinical Relevance

Image In the last ten years, placenta, fetal membranes (i.e. amnion and chorion), and amniotic fluid have been extensively investigated as a potential non-controversial source of stem cells. They are usually discarded after delivery and are accessible during pregnancy through amniocentesis and chorionic villus sampling. Several populations of cells with multi-lineage differentiation potential and immunemodulatory properties have been isolated from the human placenta and fetal membranes; they have been classified by an international workshop as human amniotic epithelial cells (hAECs) [human amniotic mesenchymal stromal cells (hAMSCs) human chorionic mesenchymal stromal cells (hCMSCs) and human chorionic trophoblastic cells (hCTCs). In the amniotic... Read More

The Role of GroE Chaperonins in Developing Biocatalysts for Biofuel and Chemical Production

Image As the need and interest for producing renewable biofuels and biochemical has grown, new avenues to improve product yields and productivity have been explored. Specifically, improving the tolerance of host microbes towards stressors, such as heat shock or the presence of harmful solvents, has been an especially important route to improve industrial-scale chemical production. In this review, we discuss recent advances in microbial engineering for renewable chemical production through the introduction and expression of chaperonins, especially the bacterial GroE complex. The GroE complex provides a closed-off environment and allows vital proteins to enter and engage in post-translational folding or refolding... Read More

Neutrophil-mediated skin diseases: immunology and genetics

Image Neutrophil-mediated skin diseases encompass a wide spectrum of diseases characterized by polymorphic cutaneous manifestations. They are histopathologically hallmarked by sterile neutrophilic infiltrates involving the skin and, more rarely, the internal organs. Neutrophil-mediated skin diseases share clinicopathological features with those of autoinflammatory diseases, which present in patients with recurrent episodes of aseptic inflammation in the affected organs in absence of allergy or frank autoimmunity. In classic autoinflammatory diseases, mutations in genes regulating innate immune responses leads to altered activation of the inflammasome. The inflammasome is a molecular platform responsible for triggering autoinflammatory processes via the uncontrolled release of interleukin (IL)-1β, as... Read More

Inflammation in Healing and Regeneration of Cutaneous Wounds

Image Cutaneous wounds are a largely unrecognized, spiraling epidemic that affects millions of people worldwide. Healing and regeneration of wounds is a complex process that has at its core a functional inflammatory response that initiates the repair process and fights against infective pathogens. Wound inflammation is a tightly regulated process involving neutrophils, macrophages, mast cells, and various leukocytes and tissue restoration mechanisms working in concert to allow healing and tissue restoration following injury. However, in many conditions, dysregulated and/or prolonged inflammation leads to the development of chronic wounds and contributes to excessive scar formation. Over the past few decades, scientific advances... Read More

Purification Propensity for Proteins from Bacillus halodurans

Image The demand for proteins with special purposes increases significantly. These proteins are generally obtained through recombinant proteins; however their purification is costly and not easy. It is necessarily important to develop a method to estimate the chance of purification beforehand in order to have a prospective on proteins in question. Purification of a protein should be related to instinct properties of a protein including its 3D structure, and so far around 540 amino acid properties are found. Thus it is possible to test each amino acid property against the successful rate of protein purification to find out which property is... Read More

Modeling Analyses on the Success Rate of Purification of Saccharomyces cerevisiae Proteins

Image Saccharomyces cerevisiae is the most widely used yeast in research and industries, however the downstream processes for its protein production are costly. This study attempted to find out a simple way to predict the success rate of protein purification with amino acid features. Logistic regression and neural network model were used to test each of 535 amino acid features one by one against the purification state of 1294 expressed proteins from S. cerevisiae, of which 870 were purified. The results show that the predictive performance of neural network is more powerful than that of logistic regression. Some amino acid features... Read More

Impacted Cera Septal Occluder Device in Right Ventricular Outflow Tract

Image Journal of Perioperative Medicine is an open access journal that publishes highly topical clinical research relating to the perioperative care of surgical patients.  Journal of Perioperative Medicine   essence is the distillation, examination and application of clinical evidence to improve surgical outcome. Modern perioperative medicine is a true multidisciplinary speciality and the journal welcomes research in all areas relevant to perioperative medicine from any healthcare professional. Main areas of interest include but are not limited to: Perioperative outcomes (surgical, anesthetic, medical), Evidence-based care, Perioperative guidelines and consensus statements, Preoperative evaluation and risk scores, Preoperative testing,... Read More

Insights to Ultrasound Technology

Image  An ultrasound scan finds its applications in medical and research field . The ultrasound technology uses high-frequency sound waves to create images of the internal organs of the body. The major benefit of ultrasound is it does not utilize or emit any radiation that causes harm to the human body. Thus it is also suitable for use during pregnancy.An ultrasound is recommended for heart, kidneys, bladder, brain (in infants), eyes, liver, ovaries, pancreas, spleen, thyroid and other body organs. Another important application of ultrasound is found under water where an  ultrasonic pulse is generated in a specified direction . This... Read More

Torsion of Para-Ovarian Cyst

Image Single-Blind Peer Review Journal devoted to the clinical practice of anaesthesia. Journal of Perioperative Medicine a wide range of articles in the discipline of anesthesiology including basic science, translational medicine, education, and clinical research to create a platform for the authors to make their contribution towards the field without restrictions/ barriers of subscription and language. Journal of Perioperative Medicine addresses all aspects of anaesthesia practice, including anesthetic administration, pharmacokinetics, preoperative and postoperative considerations, coexisting disease and other complicating factors, cost issues, and similar concerns anesthesiologists contend with daily. Exceptionally high standards of presentation and... Read More

Sarcoidosis – the great mimicker

Image Sarcoidosis is a granulomatous disease of unclear etiology with the potential affection of major organs. It most commonly affects the lungs, skin, eyes, and lymph nodes. Less frequent, though possibly underestimated, manifestations are rheumatic and renal disease. As a systemic disease, it can present in numerous ways and mimic many other conditions, including infections and cancer. While it has been proposed that an abnormal immunologic response to antigens leads to granulomatous inflammation in genetically predisposed individuals, much has to be learned. Sarcoidosis can present as an acute and self-limiting disease or progress to a chronic and potentially debilitating disorder. The... Read More

Advance In B-cell therapies for the Treatment of Rheumatic Disease

Image B-cells have multiple pathogenic roles in rheumatic and musculoskeletal diseases (RMDs). The two most evaluated strategies for B-cell blockade over the last two decades are B-cell depletion and inhibition of B-cell survival factors (BAFF and/or APRIL). Rituximab, a chimeric monoclonal antibody depletes B-cells by targeting CD20, although the depth, duration of depletion and clinical response may vary between patients. Recent data have supported the efficacy of reduced rituximab dose and the different retreatment strategies in both its licensed indications; rheumatoid arthritis and granulomatosis with polyangiitis/microscopic polyangiitis, although long-term data are still needed to establish the optimal approach. Despite the failure... Read More

Cephalosporin C Production from Acremonium chrysogenum

Image Cephalosporin C demand is increasing worldwide because of its enhanced antibacterial spectrum that it can be used to treat diseases and infections caused by Gram positive/or Gram negative bacterial strains. Cephalosporin C is easily produced from the fungus Acremonium chrysogenum by the process of fermentation in a bioreactor under optimum reaction conditions to obtain maximum yield of the antibiotic. Additional chemical and structural modifications in the existing cephalosporin C could further enhance its antimicrobial spectrum. Acremonium chrysogenum also known as Cephalosporium acremonium is the industrial producer of the antibiotic cephalosporin C, a beta-lactam antibiotic. Today cephalosporin and its derivatives are... Read More

Protein–Protein Interaction

Image Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forceshydrogen bonding and the hydrophobic effect. Many are physical contacts with molecular associations between chains that occur in a cell or in a living organism in a specific biomolecular context Proteins rarely act alone as their functions tend to be regulated. Many molecular processes within a cell are carried out by molecular machines that are built from numerous... Read More

Management of On-going Antiplatelet Treatment in Elderly Patients

Image Journal of Perioperative Medicine is a peer reviewed, open access periodical that underlines the importance of pre-operative medical care, procedures and protocols in assuring stress free and healthy post-operative life of the patient. Journal of Perioperative Medicine aims to publish the most reliable and complete information on discoveries and current developments in the form of research articles, review articles, case reports and short communication. All articles are peer reviewed and published under the guidance of our Editorial Board members. The published articles are made freely and permanently accessible online immediately upon publication, thus improving... Read More

Anaesthesia and Perioperative Care

Image Journal of Perioperative Medicine (JPME) is an international, peer reviewed, open access journal committed to publish innovative research in the field of anaesthesia and pain medicine. Anaesthesia means temporary ‘loss of sensation or awareness' usually given as gas to breathe in, injections, ointments, drops or sprays to stop the painless performance of medical procedures. It is usually given as gas to breathe in, injections, ointments, drops or sprays. Journal of Perioperative Medicine provides a broader platform to discuss a wide range of topics in this field including Local Anesthesia, Sedation, Regional Anesthesia, Anesthetic Agents,... Read More

Enzyme Expression

Image The metabolic enzyme expression remodelling is now widely known as hallmark of cancer, but it is not clear whether individual metabolic strategies are frequently exploited by many tumours. The highest scoring pathway is mitochondrial one-carbon metabolism and protein are markedly elevated in many cancers and correlated with poor survival in breast cancer. In this it shows the importance of mitochondrial compartmentalization of one carbon metabolism in cancer and raises important therapeutic hypotheses. Enzymes are an important staple in the biopharmaceutical, agricultural and chemical fields. However, expression of these workhorse proteins comes with a number of problems as well. Bacterial hosts... Read More

Bioprocess

Image A bioprocess is a specific process that uses complete living cells or their components (e.g., bacteria, enzymes, chloroplasts) to obtain desired products. Transport of energy and mass is fundamental to many biological and environmental processes. Areas, from food processing (including brewing beer) to thermal design of buildings to biomedical devices to pollution control and global warming, require knowledge of how energy and mass can be transported through materials (momentum, heat transfer, etc.). Cell bioprocessing: Cell therapy bioprocessing is a discipline that bridges the fields of cell therapy and bioprocessing (i.e., biopharmaceutical manufacturing), and is a sub-field of bioprocess engineering.... Read More

Biomaterials for Skin Wound Repair

Image It is often overseen that the skin or integument is the biggest organ of the human body. Moreover, skin importance spans different fields, from esthetics and social interactions to various diseases and their multiple upshots. Notably, skin and internal organs are bidirectionally related: an organ disease can alter skin structure and function, and vice versa. An example of this mutual relationship is acute or chronic urticaria (hives) with or without angioedema, which affects wide skin areas and is caused by immune reactions to foreign antigens, autoimmunity, malignancy, and so on. The reverse example is a deep and extended burn wound... Read More

Hair Follicle Stem Cell Regeneration in Aging

Image Tissues and organs undergo structural and functional declines in the aging process, with a gradual decrease in regenerative ability. The hair follicle is a complex mini-organ that undergoes cyclic self-renewal during postnatal life, as the follicle contains stem cells that can be activated and silenced cyclically. Thus, it serves as an excellent model for studying regeneration. However, follicles gradually lose hairs and stem cells enter quiescence or differentiate into other skin epithelial lineages during aging. This process is largely influenced by intrinsic epigenetic status and extrinsic environmental factors which affect the hair follicle stem cell behavior during hair cycling. In... Read More

Malassezia: A Skin Commensal Yeast Impacting Both Health And Disease

Image Malassezia yeast existS on all humans and have long been associated with healthy and diseased skin. In this Article Collection of Frontiers in Cellular and Infection Microbiology; Fungal Pathogenesis, we will present multiple papers outlining the state of the art in understanding the role Malassezia in skin health and disease. Over the last thirty years, the term “microbiome” has grown exponentially in scientific discourse, generating hundreds of thousands of publications and patents. Although the human-associated microbial community consists of bacteria, fungi, viruses, and archaea, the vast majority of these publications have been limited to gut bacteria. Only in the two... Read More

Genetics in Human Skin Diseases

Image Over the past decades, large numbers of genes and genomic regions involved in human complex diseases have been revealed through linkage analysis, candidate gene study, and genome-wide linkage study. These help to determine the position of the genetic marker inherited with a complex disease. Since 2005, genome-wide association studies (GWAS) have been proved to be the most powerful and efficient study design for identifying genetic variants that are associated with complex diseases. More than twenty kinds of skin diseases and traits have been investigated by this approach including psoriasis, SLE, leprosy, vitiligo, and atopic dermatitis. Recently, Next-Generation DNA Re-Sequencing and... Read More

The Role of Enzymes in Metabolism

Image Metabolism is chemical reactions occurring in organisms. Without enzymes metabolism wouldn’t be fast enough to support life. Metabolism refers to all the chemical reactions occurring in organisms. Chemical composition: Enzymes are made of protein. Protein consists of one or more polypeptide chain. These are made of long chains of amino acids connected by peptide bonds. Structure of Enzymes: In enzymes, the polypeptide chain is folded into a 3D shape. A part of the enzyme is called the active site. This attaches to the substrate The substrate is molecules the enzymes act upon. Specific of enzymes: ... Read More

Role of Enzymes in Detergents

Image The original idea of using enzyme as detergents was described in 1913 by Dr Otto Rohm, who patented the use of crude pancreatic extracts in laundry pre-soak compositions to improve the removal of biological stains. In the same year, the first enzymatic detergent named Burnus was launched, but was not popular because of its own limitations. Subsequently, Bio- 40 - a detergent containing a bacterial protease was produced in Switzerland and launched in the market in1959 and it gradually became popular. In the period from 1965 to 1970, use and sale of detergent enzymes grew very fast. In 1970, the... Read More

Potential Challenge for the Anaesthesiologist

Image Journal of Perioperative Medicine is multidisciplinary medical field related to perioperative care of surgical patients. Journal of Perioperative Medicine is medical patient care from the time of contemplation of surgery to recuperate from surgical period to improve the surgical outcome. Surgeon, anesthetist, intensivist and physician work closely in such field. However anesthetist play major role in perioperative medicine from pre anesthesia check prior to surgery. Journal of Perioperative Medicine provides a broader platform to discuss a wide range of topics in this field including Local Anesthesia, Sedation, Regional Anesthesia, Anesthetic Agents, Nerve Blocks, Spinal,... Read More

Biochemical Changes and Cardiovascular Function

Image Clinical & Medical Biochemistry  covers the research areas in the field of Clinical Biochemistry, Pathological, Microbiological, Molecular, Cellular, Genetic and Bioinformatics concepts and other advanced techniques. The journal primary mission to serve the public interest in health care by providing leadership in clinical laboratory science to national professional societies, the diagnostics industry, government and non-government organization. Journal of Clinical and Medical Biochemistry also acts as a bridge in various interdisciplinary areas of medicine. It covers laboratory accreditation programmes pertaining to health and disease. Clinical biochemistry is a special branch of medicine dealing with measurement... Read More

Recent Advances in Clinical Enzymology

Image The past year has seen a wider application of knowledge originating over the last decade rather than startling new developments. For brevity, only serum enzymes will be considered and the points at which progress is being made are indicated by the sectional headings which follow. ENZYME METHODOLOGY: Considerable change is taking place in established enzyme methods and new forms of methodology are being developed. Colorimetric kinetic assays Together with the familiar ultraviolet (UY) kinetic assays, newer kinetic assays utilising wavelengths in the visible part of the spectrum are proving increasingly popular. They have been rendered possible by the increasing... Read More

Call for Research Papers-Enzyme Engineering

Image Enzyme Engineering [EEG] is a peer-reviewed journal that offers researchers and scholars in-depth useful reviews and research trials and surveys of new and novel approaches in the field of Enzymology and Clinical Sciences. Each peer-reviewed issue assesses practice issues; practice settings; therapeutics issues; disease management; the latest research; as well as issues arising from today’s emerging health-care research. Journal Aim EEG was started with an aim to support the wider scientific community working in the field of Enzymology and associated disciplines. It looks forward to provide the academicians, researchers and future generations a forum to publish... Read More

Cutaneous B-cell Lymphomas

Image Primary cutaneous lymphomas (PCLs) are non-Hodgkin lymphomas that are present only in the skin at the time of diagnosis, and without evidence of extracutaneous manifestations. Among extranodal non-Hodgkin lymphomas, PCLs are the second most frequently observed type after gastrointestinal lymphomas. PCLs occur at an incidence of 1 per 100,000 persons annually, and about 25% to 30% of all are Cutaneous B-cell lymphomas (CBCLs). CBCLs can be further classified according to clinical behavior as either aggressive or indolent. Indolent CBCLs include primary cutaneous marginal zone lymphoma (PCMZL) and primary cutaneous follicle center lymphoma (PCFCL), whereas the aggressive CBCLs are diffuse large... Read More

Application of Computed Tomography on Bovine and Malignant Tumors

Image Journal of Molecular Imaging & Dynamics is glad to disseminate knowledge on the “Computed Tomography: A Reliable Modality for the Assessment of Bowel Wall Thickening to Categorize Benign and Malignant Lesions of Bowel WallGist of the study : Presently, CT is considered the first-line modality for the evaluation of a variety of small and large bowel diseases. A wide spectrum of intestinal wall morphologic and enhancement abnormalities can be seen with bowel disorders. Once an abnormality is detected, the radiologist needs a systematic approach for determining the specific cause of... Read More

Evaluation of the Ophthalmology

Image Publishing highly topical clinical research relating to the perioperiative care of surgical patients, Journal of Perioperative Medicine  aims to disseminate the distillation, examination and application of clinical evidence to improve surgical outcome. Understanding that modern perioperative medicine is a multidisciplinary speciality, we welcome research in all areas relevant to perioperative medicine from any healthcare professional. Journal of Perioperative Medicine is an informative professional journal which provides current evidence-based practice, clinical, management and educational developments for practitioners working in the perioperative environment. The journal promotes perioperative practice by publishing clinical research-based articles, literature reviews, topical... Read More

Nursing, Education and Perioperative Care

Image Journal of Perioperative Medicine is an open access journal that publishes highly topical clinical research relating to the perioperative care of surgical patients. Its essence is the distillation, examination and application of clinical evidence to improve surgical outcome. Modern perioperative medicine is a true multidisciplinary speciality and the journal welcomes research in all areas relevant to perioperative medicine from any healthcare professional. Journal of Perioperative Medicine  focusing on technologies, medical devices, apps, engineering, informatics and patient education for perioperative medicine and nursing, including pre- and post-operative education, preventative interventions and clinical care for surgery... Read More

Aspiring good health of Mother and Neonate

Image  Journal of Pregnancy and Neonatal Medicine is an online open access journal considers articles on all aspects of pregnancy and childbirth. Journal of Pregnancy and Neonatal Medicine includes the focusing on all the aspects of pregnancy, breastfeeding, labour, maternal health, maternity care, trends and sociological aspects of pregnancy and childbirth. Journal of Pregnancy and Neonatal Medicine is the practical, research-based journal for all professionals concerned with the care of neonates and their families, both in hospital and the community. JPNM aims to support the development of the essential practice, management, education and health promotion... Read More

Scope and Growth of Perioperative Medicine

Image   Perioperative medicine encompasses the care of the patient preparing for, having and recuperating from surgery. In the practice of perioperative medicine the surgeon, anaesthesiologist , intensivist and medical consultant work in concert. The medical knowledge distinct to this field includes that of operative risk and complications, of patient specific risks, of methods to reduce risk, and of the management of medical illness during this time period. Evidence supporting best practices in perioperative medicine is expanding, though historically this field has been directed by common practice and experience. It remains a field governed primarily... Read More

Clinical and Medical aspects of Biochemistry

Image Journal of Clinical and Medical Biochemistry (cmbo) is a journal which publishes original research communications, review articles, case reports, letters to the editor in the field of medical biochemistry and laboratory medicine. The objective of the journal is to publish novel information leading to a better understanding of biochemical mechanisms behind the pathogenesis, diagnosis, and management of human diseases. Journal of Clinical and Medical Biochemistry publishes original scientific and specialized articles on all aspects of clinical chemistry, medical biochemistry and related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry are dealing with the... Read More

Biochemistry and Medical Science

Image Medical Biochemistry is a branch of medicine that represents a unique integration of basic biochemical science and clinical medicine. In addition to acting as an effective consultant for clinical colleagues, medical biochemists are trained with the knowledge and skills necessary to operate and manage clinical biochemistry laboratories. The practice of medical biochemistry is privileged to be in tertiary care centres’, as part of a multidisciplinary team including scientists and technologists. Journal of Clinical & Medical Biochemistry covers all the fields of Clinical & Medical Biochemistry related to Clinical biochemistry, Immunology, Genetics,... Read More

Affectivity beyond the Skin

Image This Research Topic will be an interdisciplinary collection of papers by philosophers, psychologists and social scientists. The proposed topic is an exploration of the scaffolded or environmentally supported nature of affectivity. Standard approaches in philosophy and psychology characterize affective states (such as specific emotions and moods) as states of a person’s brain and body. This Research Topic will explore the extent to which affective states also importantly depend upon structures and processes in the environment. In particular, it will explore the way in which people actively manipulate their surroundings to create what we can call affective niches: self-styled environments that... Read More

Applications of Enzymes in Our Daily Life

Image Here are some examples of enzyme biotechnology you might use every day in your own home. In many cases, the commercial processes first exploited naturally occurring enzymes. However, this does not mean the enzyme(s) being used were as efficient as they could be.With time, research, and improved protein engineering methods, many enzymes have been genetically modified. These modifications allow them to be more effective at the desired temperatures, pH, or other manufacturing conditions typically unsuitable for enzyme activity (e.g. harsh chemicals). They are also more applicable and efficient for industrial or home applications. I. Application in feed The use of... Read More

Enzyme Engineering: Explore your Research Work-New Edition

Image Enzyme Engineering [EEG] is a peer-reviewed journal that offers researchers and scholars in-depth useful reviews and research trials and surveys of new and novel approaches in the field of Enzymology and Clinical Sciences. Like the Anesthesia research, topics are diverse. Recent topics have included focussing on Enzyme Research: Bioprocess Cross Linking Enzyme Expression Enzyme Kinetics Insilco Design of Enzymes Protein Interaction Protein Peptide Interactions Computation Protein Design Enzyme Catalyst Enzyme Immobilisation Enzyme Purification Ionic Bonding Protein Ligand Binding Protein-Protein Complexes Covalent Binding Enzyme Engineering Enzyme Inhibition Enzymes Metabolic Pathway Engineering Protein Nucleotide Each peer-reviewed issue assesses practice... Read More

Tactile Stickiness Perception

Image "The bandage keeps coming off my arm, but it definitely sticks to my fingertip." Some people might have a similar experience. From this phenomenon, we can bring up several interesting questions. Why does the stickiness vary from location to location on the skin? What information is computed from the sticky surface elements and how? What is the relationship between physical and perceptual stickiness? Unfortunately, at the moment, little information is mounted to answer these questions. Previous studies revealed that the tactile sense of stickiness is aroused when the skin is stretched as people detach their body from an adhesive substance.... Read More

Insights into Biomarkers, Cytokines, and Chemokines in Skin Cancer

Image Understanding the microenvironment within skin cancers is key for the development of new preventative and therapeutic treatment options. Research advances in skin cancers such as melanoma have revolutionized immunotherapeutic treatment options, for example through the provision of checkpoint inhibitor trials that have benefitted not just melanoma patients, but also patients with a wide array of other cancers, including less readily accessible cancer types. However, checkpoint inhibitor success is limited in melanoma and unlikely to become the mainstay of treatment for other skin cancer types like squamous cell carcinoma. Therefore, many skin cancer subtypes remain with few treatment options and there... Read More

Medical Biochemistry and Its Applicative Arm

Image The Journal of Clinical and Medical Biochemistry publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical haematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings. Journal of Clinical and Medical Biochemistry... Read More

Science and Forensic Medicine

Image Journal of Forensic Medicine (JFM) publishes topical articles on aspects of forensic and legal medicine. Specifically the Journal supports research that explores the medical principles of care and forensic assessment of individuals, whether adult or child, in contact with the judicial system. It is a fully peer-review hybrid journal with a broad international perspective. Journal of Forensic Medicine (JFM) is a peer reviewed journal, serving the International Scientific Community. This forensic medicine journal with impact factor offers an Open Access platform to the authors to publish their research outcome. Journal of Forensic Medicine(JFM) is... Read More

Care of the Mother and Neonate

Image   Journal of Pregnancy and Neonatal Medicine(JPNM) is an open access, peer reviewed, scholarly journal that focusses on the publication of research developments in the various aspects of fertility, pregnancy, child birth and neonatal care. Pregnancy and neonatal medicine research are of high significance and it is indispensable for assuring the good health of new mothers and babies. Journal of Pregnancy and Neonatal Medicine(JPNM) integrates both the topics and aims towards contributing in the furtherance of research in the field of obstetric medicine and neonatal medicine. Journal of Pregnancy and Neonatal Medicine(JPNM) publishes a... Read More

Development and testing of perioperative medicine

Image Journal of Perioperative Medicine (JPME) is an open access journal that publishes highly topical clinical research relating to the perioperative care of surgical patients. Its essence is the distillation, examination and application of clinical evidence to improve surgical outcome. Modern perioperative medicine is a true multidisciplinary speciality and the journal welcomes research in all areas relevant to perioperative medicine from any healthcare professional. Journal of Perioperative Medicine provides a broader platform to discuss a wide range of topics in this field including Local Anesthesia, Sedation, Regional Anesthesia, Anesthetic Agents, Nerve Blocks, Spinal, Epidural and... Read More

Combination strategies in the treatment of Melanoma

Image For many years melanoma was considered a significant challenge by oncologists. In 2011 the story changed because of the approval of ipilimumab, an anti-CTLA4 monoclonal antibody, and vemurafenib, a BRAF inhibitor active on BRAF mutated melanoma. These two revolutionary drugs completely changed the management of metastatic melanoma and, for the first time, became possible to achieve a significative impact on overall survival. To improve the efficacy of ipilimumab and vemurafenib have been designed clinical trials, now ongoing, of combination with other targeted agents (e.g. MEK inhibitors) and immunotherapeutic compounds (e.g. anti-PD-L1). Other possible combinations of these two new drugs can... Read More

New Trends in Journal of Developing Drugs

Image Journal of Developing Drugs is an open access publishing that aims to focus on the Drugs, and also related to Chemistry and Pharmacy. Journal of Developing Drugs deals with chemical compounds found in Drugs that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery and drug design. Articles such as original research papers, review articles, short communications, case reports and commentaries are welcome. Articles related to Drug Metabolism, Drug Designing, Clinical Trails, Drug Discovery, Biopharmceutics, Pharmacokinetics and Pharmacodynamics of the Drugs. The main aim of the Journal of Developing Drugs and Research is to publish high... Read More

Enzymes and its Role

Image Enzymes are known to catalyze more than 5,000 biochemical reaction types.Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Enzymes are sensitive to external conditions and therefore have unstable characteristics. High temperature, strong acid, alkali and some heavy metal ions will lead enzyme to lose activity and useless. Enzymes are generally difficult to preserve, which brings great difficulties to a wide range of applications. According to the function of the enzyme, enzymes are usually divided into six categories: A. oxidoreductases, including sub-oxidase and dehydrogenase, which are involved in productivity, detoxification and the synthesis... Read More

Enzymes and its Evolution

Image Enzyme is a kind of catalytic protein produced in the body, functioning as a catalyst. The catalyst can accelerate the chemical reaction without the change of amount and chemistry after the chemical reaction. All enzymes are macromolecules made up of many amino acids with a molecular weight between 10,000 and 1,000,000. Natural enzyme molecules include simple enzymes and binding enzymes. The former molecular composition contains only protein, the latter contains non-protein components, as well as protein composition. Some also contain metal ions. Non-protein components in enzymes are known as cofactors. The combination of cofactors and enzyme proteins is called holoenzyme.... Read More

Biomedical Research: Grab and bag huge citations with BMR

Image Biomedical Research: Grab and bag huge citations with BMR Biomedical Research (BMR) is a peer-reviewed journal that offers researchers and scholars in-depth useful reviews and research trials and surveys of new and novel approaches in the field of Biological and medical sciences. Like the biomed research, topics are diverse. Recent topics have included focussing on Thyroid Research: Goiter Graves’ Disease Hashimotos Thyroiditis Hyperthyroidism Hyperthyroidism Symptoms Hypothyroidism Hypothyroidism Symptoms Iodine Deficiency Iodine Supplements Levothyroxine Parathyroid Hormone Thyroid Cancer Thyroid Gland Thyroid Nodules Thyroid Symptoms Thyroid Test Thyroid Treatment Thyroidectomy Thyrotoxicosis Thyroxine TSH Levels TSH Test Each... Read More

Sleep and Aging

Image Life expectancy is on the rise worldwide. Within the US alone, it is estimated that 20% of the population will be over the age of 65 years by 2030. Normal aging results in a relentless deterioration of both sleep and wakefulness. This includes sleep fragmentation and the inability to sustain wakefulness during the active phase in humans and rodents. Impairments in both behavioral states become more pronounced in many age-dependent neurodegenerative processes. Impaired wakefulness interferes with cognitive function and quality of life for millions of older Americans. Recent data indicates that sleep disruption and disorders might themselves contribute to the... Read More

Skin Blistering Diseases

Image Skin blistering is commonly caused by mechanical, physical or infectious insults. More rarely, mutations of structural components of the skin or autoimmunity directed against those structural components lead to skin blistering. Skin blistering is commonly caused by mechanical, physical or infectious insults. More rarely, mutations of structural components of the skin or autoimmunity directed against those structural components lead to skin blistering. Albeit among the less frequent causes of skin blistering, understanding of the pathomechanisms of hereditary and autoimmune skin blistering has provided detailed insights into cutaneous biology and (auto)immunity. In recent years, genetics, definition of autoantigens, model systems and... Read More

The Infinite Possibilities of Enzyme Engineering

Image Protein engineering is a powerful tool in synthetic biology that can create proteins with tremendous potential for therapeutic and industrial use. The field has recently taken giant leaps forward from its origins, and some of its pioneers predict that the next five to ten years hold exponentially more promise. Early protein engineering was what David Baker, Ph.D., director of the Institute for Protein Design at the University of Washington, called “Neanderthal protein design.” “You’d look around in nature for something where you could make a couple of amino acid substitutions.  It’s like when early humans needed a tool, they’d sharpen... Read More

Applications of Enzyme Engineering for Better World

Image Engineered proteins can be used to optimize desired traits in plants; even though recent advances have resulted in new application areas, certain methodological challenges remain. Protein engineering and directed evolution are powerful technologies for probing protein sequence-function relationships. These methods have been used to engineer both plant-derived proteins and exogenous proteins heterologously expressed in plants. In this review, we aim to further increase the interdisciplinary crossover between the disciplines of protein engineering and plant biology by first introducing protein engineering in some detail. This introduction is key to understanding current limitations to protein engineering when applied to plants. Subsequently, we... Read More

Biologic Drugs in Autoimmune Diseases

Image In the current therapy of autoimmune disease, a significant progress has been made in terms of introducing novel, mostly biologic, drugs in place of chemical molecules. These biologic agents enhance or replace conventional immunosuppressive therapies. Their mechanism of action consists in disrupting the inflammatory process. The categories of biologics include inhibitors of tumor necrosis factor, interleukins, T cells, B cells, or JAK. Biologics, or biologic-response modifiers, may be prescribed for the treatment of autoimmune diseases, including many types of arthritis (e.g., rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis), as well as inflammatory bowel diseases or psoriasis. Biologics exert significant clinical... Read More

Resveratrol and Breast Cancer (STUDY)

Image Researchers demonstrate that resveratrol, the ingredient which is found in red wine, prevents the growth of breast cancer cells by stopping the growth effects of estrogen. These study results suggest that resveratrol is capable of counteracting the malignant progression as it suppresses the spreading of hormone resistant breast cancer cells. The discovery has significant implications for treating breast cancer in women whose tumors at some point develop a resistance to hormonal therapy. The researchers made use of a number of breast cancer cell lines that express the estrogen receptor in order to evaluate the effects of resveratrol. The different cells... Read More

Type 2 Diabetes Drugs and Pancreatic Cancer Association

Image According to a study, 2 drugs made use of for treating type 2 diabetes may be associated with a significantly higher risk of the development of pancreatic cancer and pancreatitis, and 1 of the drugs may be associated with an increased thyroid cancer risk. Researchers analyzed the FDA’s database for adverse events reported by individuals making use of the type 2 diabetes drugs exenatide and sitagliptin. A 6 times the increase in the odds ratio for reported pancreatitis cases with these drugs was found, in comparison to 4 other diabetes control therapies. It was also found that individuals using the... Read More

Autoinflammatory Keratinization Disease (AiKD)

Image As the research in the field of Dermatology has been increasing day-by-day, the clinical investigations and trails are also been advanced. Inflammation caused by the hyper-activation of innate immunity due to genetic factors occasionally leads to inflammatory keratinization diseases of the skin. Such inflammatory keratinization diseases with genetic autoinflammatory pathogeneses are called “autoinflammatory keratinization diseases” (AiKD). AiKD also includes diseases with mixed pathological mechanisms of autoinflammation and autoimmunity. AiKD have primary genetic causative factors associated with autoinflammation mainly in the epidermis and the upper dermis. Autoinflammation in the epidermis and the upper dermis leads to hyperkeratosis in the skin, resulting... Read More

Call from Enzyme Engineering: Open-Access (Volume 8: Issue: 2)

Image Enzymes have played an important role in many aspects of life since the dawn of time. In fact they are vitally important to the existence of life itself. Civilizations have used enzymes for thousands of years without understanding what they were or how they work. The French chemists Anselme Payen and Jean-Franois Persoz described the isolation of an amylase complex from germinating barley and named it diastase. Like malt itself, this product converted gelatinized starch into sugars, primarily maltose. In 1835 the Swedish chemist Jöns Jacob Berzelius demonstrated that starch can be broken down more efficiently using... Read More

Scope of Enzyme Engineering for Better Science World

Image Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field of enzymology and enzyme engineering. Our journal promulgates all current issues that take place in betterment in the field of Life sciences. The Editorial Board of our journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage... Read More

Skin Autoimmunity

Image In the last few decades, autoimmune diseases have become a major clinical burden. The reasons for this are manifold, including (i) increasing incidence; (ii) the lack of therapies that target the underlying cause of the specific disease in question and (iii) the high rate of adverse events due to prolonged, unspecific immunosuppression. The skin is one of the largest organs of the human body and several autoimmune diseases manifest at the skin. These include skin-specific autoimmune diseases and cutaneous manifestations of systemic autoimmune diseases. Furthermore, with the recent success of immune checkpoint therapy in cancer, immune-mediated adverse effects on the... Read More

Cosmeceuticals from Medicinal Plants

Image If "drugs" have been defined as compounds used in the treatment and prevention of diseases, or are intended to affect a physiological function, "cosmetics" have been labelled as substances that clean or enhance the appearance of the skin without therapeutic benefits. There is also a grey area bordering these two fields, for which the term "cosmeceuticals" has been defined. “Cosmeceuticals” are described as hybrids between drugs and cosmetic products which are able to enhance both health and beauty of the skin by external application. Cosmeceuticals, bridge the gap between pharmaceuticals, skin diseases and cosmetics. ‘Cosmeceuticals’ are topical cosmetic-pharmaceutical hybrids intended... Read More

Join our Editorial Board - Chemotherapy: Open Access

Image Chemotherapy: Open Access (CMT) [ISSN: 2167-7700, Index Copernicus Value: 62.73] is one of the best Open Access journals publishes the relevant and reliable information on the discoveries and current developments and all other areas of the field and making them freely available online without any restrictions or any other subscriptions to researchers worldwide. The journal provides multi-disciplinary interpretation of the latest research advances in different aspects of therapeutic techniques such as Cytotoxic, Electro, and the antimicrobial chemotherapies used to treat several dreadful diseases, particularly Cancer. It also accepts... Read More

Chemotherapy: Open Access - Call for Papers

Image Chemotherapy: Open Access (CMT), is one of the best Open Access journals publishes the relevant and reliable information on the discoveries and current developments in the form of original articles, review articles, case reports, short communications, etc. and all other areas of the field and making them freely available online without any restrictions or any other subscriptions to researchers worldwide. Journal expresses its warm gratitude to especially the Editorial Board, and extending this gratitude to all the Authors, researchers, Editors and Students who have contributed their valuable researches in the form of full article, case reports to... Read More

Call to Join as Editorial Board Member :Enzyme Engineering|Open-Access

Image Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field of enzymology and enzyme engineering. Our journal promulgates all current issues that take place in betterment in the field of Life sciences. The Editorial Board of our journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage... Read More

Expertise your Research to Enzyme Engineering for Better Science

Image Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field of enzymology and enzyme engineering. Our journal promulgates all current issues that take place in betterment in the field of Life sciences. The Editorial Board of our journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage... Read More

Types of Chemotherapy - Chemotherapy: Open Access (Special Edition)

Image Antitumor Antibiotics Antitumor antibiotics are chemo treatments made of natural merchandise made by species of the soil plant life actinomycete.  These medication act throughout multiple phases of the cell cycle and are thought of cell-cycle specific.  There are many forms of growth antibiotics: Anthracyclines: antibiotic, Daunorubicin, Epirubicin, Mitoxantrone, and Idarubicin. Chromomycins:  Dactinomycin and Plicamycin. Alkylating Agents Alkylating agents are most active within the resting section of the cell.  These forms of medication are cell-cycle non-specific.  There are many forms of alkylating agents utilized in therapy treatments: Poison gas derivatives:  Mechlorethamine, Cyclophosphamide, alkalating agent, Melphalan, and Ifosfamide. Ethylenimines:... Read More

Invitation for Article Submission - Chemotherapy: Open Access

Image [ISSN: 2167-7700 | Index Copernicus Value: 62.73] Greetings from Chemotherapy: Open Access! Chemotherapy: Open Access is a prestigious Journal publishing Cancer and Chemotherapy research Articles. This unique Journal aims to publish complete and reliable source of information on the discoveries and current developments in the field of Cancer and Chemotherapy. Journal deals with various types of therapeutic techniques such as Cytotoxic, Electro, and the antimicrobial chemotherapies used to treat several dreadful diseases, particularly Cancer. It also accepts articles on immune suppressant and its application along with different aspects of chemotherapy research and chemotherapy reviews. This scientific journal... Read More

Skin Functions and Mechanisms

Image The search for further knowledge on skin functions and mechanisms is at the core of many biomedical and biopharmaceutical research programs today. The extension and complexity of the skin justifies its multiple roles, affecting all physiological processes, far beyond its “barrier” characteristics. More research on skin physiology is needed to better understand various disease mechanisms, and these need not be confined to the skin itself. Skin is also a target for new molecules, supplements, materials and even instruments, with the potential to impact the whole body. Because of its accessibility and relative dimension, it is also a model to study... Read More

Pancreatic Disorders Journal Aiming at Pancreatitis

Image On behalf of the Pancreatic Disorders & Therapy, as Editor, it is my distinct honour and privilege to inform you that, it’s been eight years we have started the Journal, now we are celebrating them 8th Anniversary and we are privileged to welcome researchers of pancreatic Disorders to our journal. As Editor it is my great pleasure and honour to welcome you to the Pancreatic Disorders & Therapy. The Journal of Pancreatic Disorders & Therapy  aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Chromatography.... Read More

Disorders in Pancreatics & Therapy

Image Pancreatic Disorders & Therapy is a peer reviewed medical journal that includes a wide range of topics in this field and creates a platform for the authors to contribute towards the journal. The editorial office promises to peer review the submitted manuscripts to ensure quality PDT is one of the best open access journal that aims to publish the most complete and reliable source of information on discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in this field and provides online access to the researchers worldwide without any... Read More

Recent Trends in Enzymes and Technology

Image Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field of enzymology and enzyme engineering. Our journal promulgates all current issues that take place in betterment in the field of Life sciences. The Editorial Board of our journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage... Read More

Recent Trends in Enzyme Engineering

Image Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field of enzymology and enzyme engineering. Our journal promulgates all current issues that take place in betterment in the field of Life sciences. The Editorial Board of our journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage... Read More

Inviting you to Join as an Editorial Board: Open Access Journal

Image Inviting you to Join as an Editorial Board: Open Access Journal    “Journal of Thyroid Disorders & Therapy” offers the most comprehensive and reliable information pertaining to the latest developments in the field. The Journal also believes in advancing new hypotheses and opinions by means of its high-quality Reviews, Perspectives, and Commentaries. Thus, the content published in the journal is original and comprehensive. Manuscripts are subjected to rigorous peer review, where acclaimed scientists that are part of the editorial board are involved in this process to add value to the research findings. The impartial and transparent review process ensures the... Read More

Journal of Depression and Anxiety accomplished 8 Years Milestone in Research Publication Journey

Image Journal of Depression and Anxiety glad to invite eminent researchers to submit their valuable research for the final issue of Volume 8 in the year 2019. On-behalf of our editorial board we welcome original research, review, case reports, opinions, editorial, image articles, commentary articles covering treatment of depression, anxiety, mood disorders, psychology, pharmacology related to depression. Key topics includes Depression, Anxiety, Mental health, Antidepressants, Emotion, Cognitive, Bipolar disorders, Post traumatic disorder, Postpartum Depression, Suicide. Journal of Depression and Anxiety is a peer reviewed scientific journal known for rapid dissemination of high-quality research. Depression Journal with high impact... Read More

Explore the Current trends in the world of Thyroid Cancer

Image Explore the Current trends in the world of Thyroid Cancer   Thyroid Cancer is a type of cancer that starts in the thyroid gland. Your thyroid is shaped like a small butterfly, and is usually found inside the lower front of your neck. It’s a gland that controls your metabolism. If it’s caught early, thyroid cancer is one of the most treatable forms of cancer. Types of Thyroid Cancer  Researchers have identified four main types: Papillary thyroid cancer. Follicular thyroid cancer Medullary cancer Anaplastic thyroid cancer Thyroid lymphoma. Risk factors Factors that may increase the risk of thyroid... Read More

Chemo and Cancer Therapies: Part 1

Image Chemotherapy: Open Access takes privilege to share the topics related to types of Chemo and Cancer Therapies. Chemotherapy (CMT) is one of the best Open Access journals publishes the relevant and reliable information on the discoveries and current developments in the form of original articles, review articles, case reports, short communications, etc. and all other areas of the field and making them freely available online without any restrictions or any other subscriptions to researchers worldwide. Let’s take a look at different types of Cancer Therapy systems: Cancer Therapies Cancer Therapies are those which are used to treat... Read More

Advanced treatments in Chemotherapy

Image A vast body of research, collected over decades, has confirmed that chemotherapy (or radiotherapy) alone is not sufficient to destroy neoplastic lesions completely. The standard routine now implemented in most hospitals is that of combining chemotherapy and/or radiotherapy alongside immunotherapies. In essence, immunochemotherapy refers to the treatment and management of disease by combining immunotherapy with chemotherapy. The goal of this combination is to improve the treatment outcome for patients with cancer by allowing for a reduction in drug dosage required to combat the cancerous cells. Through supporting a reduced drug dosage, this combination therapy can decrease the... Read More

New Therapies and Immunological Findings in Melanoma and other Skin Cancers

Image Now-a-days, dermatologists and immunologists are striving hard to develop new therapies in the field of skin cancer. In particular, immunological findings have led to the development of highly effective immune-checkpoint inhibitors for cancer. Hence, they are being highlighted and improvised in the field of skin cancer treatment. The purpose of this Research Topic is therefore to provide an up-to-date overview of immune processes and new therapies for melanoma and other skin cancers in order to further stimulate the development of new and even more successful treatments. Journal of Clinical & Experimental Dermatology Research are welcoming experts in... Read More

Journal of Enzyme Engineering Celebrating its Success Journey of 8 years By Annunciating Discounts on Article Processing Charges

Image Enzymes are known to catalyse more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction rate by lowering its activation energy. Some enzymes can make their conversion of substrate to product occur many millions of times faster. An extreme example is orotidine 5'-phosphate decarboxylase, which allows a reaction that would otherwise take millions of years to occur in milliseconds. Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field... Read More

Engineering Practices in Enzymes in Daily Life

Image Enzymes are both proteins and biological catalysts (biocatalysts). Catalysts accelerate chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyse individual steps. The study of enzymes is called enzymology and a new field of pseudo enzyme analysis has recently grown up, recognising that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudo catalytic' properties. Our Journal Enzyme Engineering (Longdom Publishers SL) is... Read More

Challenges of Acne and Rosacea Treatment

Image On behalf of the Journal of Clinical & Experimental Dermatology Research, as Editor-in-Chief, it is my distinct honor and privilege to inform you that, it’s been ten long years we have started the Journal and now we are celebrating the 10th Anniversary and it is my great pleasure and honor to welcome you to the Journal of Clinical & Experimental Dermatology Research. Journal of Clinical & Experimental Dermatology Research aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Dermatology. The open access journal is published... Read More

Journal of Forensic Biomechanics would like to celebrate its thanksgiving by Providing High Discounts on APC

Image Journal of Forensic Biomechanics is a peer-reviewed scholarly journal and aims to publish the most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. covering forensic biomechanics, Computer Forensics, sports medicine, Forensic Accounting, Forensic Assessment, head injury problems, Forensic investigation, biological material properties, Forensic Statistics, biodynamic modeling, forensic epidemiology. Quick publication and open discussion will enhance the clarity and information dissemination of a... Read More

Advanced Techniques in Biology & Medicine-Successful Journey

Image Advanced Techniques in Biology & Medicine has effectively finished its seven volumes and effectively going into the eightby 2020. On this event we heart completely welcome researchers, academicians, students and research scholars to distribute their exploration discoveries as Research articles, Case reports, Reviews, Perspectives, Short editorials and so on., towards this Journal at most elevated potential limits and top tier services. The journal has taken solid goals to serve its readers and writers by incorporating the top tier publicizing methodologies to improve the writer's insightful perceivability and intelligibility. Having set up in the year 2013,"Advanced Techniques in... Read More

On Completing Decade of Successful Publishing Journal of Vascular Medicine & Surgery Announces Special Issue Invitation

Image Journal of Vascular Medicine & Surgery (ISSN: 2329-6925) is scheduled to celebrate its 7th anniversary in the year 2020. The Journal has successfully released several issues of peer-reviewed articles collated from wide geographic locations across the world since its inception in the year 2013, in addition to several special issues and International conference proceedings. To commemorate the decade long publications services, the editorial team of the journal is planning to compile an edited special issue focusing on tending research activities Vascular Medicine & Surgery. The theme/title of the upcoming special issue is Vascular Imaging and Diagnostics, which is... Read More

More you should know about Chemotherapy: Open Access

Image Chemotherapy: Open Access takes privilege to share information with our readers about our Editorial Board members along with First and foremost Editor-in-Chief Tetsuya Konishi Professor, Department of Functional and Analytical Food Sciences. Niigata University of Pharmacy & Applied Life Sciences, Japan. Who is supporting and contributing his valuable time since long time with our Journal. Chemotherapy: Open Access Journal is honour to speak more few words about ditor-in-Chief Tetsuya Konishi, He was graduated from Tokyo College of Pharmacy. AZer completing his graduate study, he worked on radioactive tracer in drug metabolism as a research assistant at Physical... Read More

Let’s have a look at Chemotherapy: Open Access

Image Chemotherapy: Open Access is an Open Access journal that aims to publish quality articles by following stringent peer review process. The main motto of the journal is to disseminate the research knowledge worldwide shared by the Scientific Experts in the form of Research Article, Review Article, Case reports, Short Commentary, etc. The purpose of publishing excellent research information is to create a huge impact on aspiring researcher across the globe. Chemotherapy: Open Access covers a wide range of topics such as Cytotoxic, Electro, and the antimicrobial chemotherapies used to treat several... Read More

Allergy and Therapy announces International Collaborations with Research Institutes and Universities.

Image Allergy and Therapy announces International Collaborations with Research Institutes and Universities. In line with development of friendly international cooperation, Journal of Allergy and Therapy wishes to establish a long-term mutually beneficial collaboration with various Institution/University by accepting bulk submissions in the field of Allergy at a highly reduced processing fee. The ever growing pollution and lifestyle changes have caused allergic responses a regular issue especially in the urban life of human being. Considerate of this fact Journal of Allergy and Therapy (JAT) presents a spectrum of exciting information on various approaches adopted and their... Read More

Know Allergy for No Allergy

Image Know Allergy for No Allergy The Journal of Allergy & Therapy presents a spectrum of exciting information on various approaches adopted and their possible outcomes in allergy research including new strategies in diagnosis, therapy and prevention of allergic diseases. Journal of Allergy & Therapy has collaborated with numerous conferences to enable the publishing of extended versions of the abstracts presented at the conference. Various Conferences like 12th International Conference on Allergy, Asthma & Clinical Immunology. 13th International Conference on Allergy and Clinical Immunology and World Congress on Allergy and Immunotherapy have been associated with... Read More

Innovative Enzyme Engineering For A Better Health In Clinical Sciences

Image Our Journal Enzyme Engineering (Longdom Publishers SL) is an esteemed Monthly, Peer reviewed and Open-Access journal that focuses on recent innovative inventions and recent advancements in the field of enzymology and enzyme engineering. Our journal promulgates all current issues that take place in betterment in the field of Life sciences. The Editorial Board of our journal is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage... Read More

Enzyme Engineering For A Better Tomorrow In World Of Health

Image                                                                                          On behalf of our esteemed journal Enzyme Engineering (Longdom Publishers SL) is a scientific open access journal that specifies and describes the development activities conducted in the field of Medical Science. The objective of the journal is to provide a medium for scientific communication to confer about the recent advancements in Enzymology. The... Read More

Treatment advances in Dermatology and Trichology

Image Dermatology is a discipline of medical science that deals with the dermal, skin diseases and associated treatment regime. Clinical practices in relation to dermatology embrace several sub disciplines including Dermatitis, Cosmetic dermatology, Dermatopathology, Immunodermatology, Pediatric dermatology, Cutaneous lymphoma, Lesions, Melanoma, Blisters, etc. Owing to the importance of each sub discipline the Journal of Clinical & Experimental Dermatology Research renders a common platform for the discussion of various important issues. Journal of Clinical & Experimental Dermatology Research supports the scientific innovation and advancement in all related aspects of Skin, Hair and Nail... Read More

On Completing Decade of Successful Publishing Journal of Neonatal Biology Announces Special Issue-Care of the infant affected by Neonatal Abstinence Syndrome

Image Journal of Neonatal Biology (ISSN: 2167-0897) is scheduled to celebrate its 9th anniversary in the year 2020. The monthly journal has successfully released several issues of peer-reviewed articles collated from wide geographic locations across the world since its inception in the year 2012, in addition to several special issues. To commemorate the decade long publications services, the editorial team of the journal is planning to compile an edited special issue focusing on tending research activities in Neonatal. The theme/title of the upcoming special issue is Care of the infant affected by Neonatal Abstinence Syndrome. The main focus... Read More

Endocrinology & Metabolic Syndrome Accomplished 8 Years Milestone in Research Publication Journey

Image Endocrinology & Metabolic Syndrome celebrates its 8 years of existence in the field of medical research publication and extends a very warm welcome to all the authors, researchers, editors and students across the world to contribute their latest research findings as full-length articles to this collaborative medical journal. Endocrinology & Metabolic Syndrome started in the year 2011 and now established as one of the most reputed journals of LONGDOM publishing group, a collaborative medical publisher, known for its close-knit association with medical societies and agencies engaged in medical research. The journal has been publishing the most recent developments... Read More